Short answer is yes.
Longer answer is that it would be tough/dangerous (maybe).
-First off, I have never seen even unloaded friction primer compatible cartridges. Really nice quality percussion cartridges are around at $250 a pop. I suspect that I will, eventually, get my hands on the earlier cartridge. I also expect that it is going to cost north of $500. So, yeah, one might get the ammo.
-The bore is a bit rough. I would not wish to be near it if it were fired.
-Because of the roughness in the chamber, cartridge extraction might prove to be challenging.
-One could, a la the CSA and their Whitworth guns, weld the breech shut and use it as a muzzleloader.
But in terms of packing it off and attacking the Spanish in the Philippines? No.
Then again, remember that John Browning made a lever action rifle fire full auto ... because he could. Anything is possible.